Olasunkanmi, Adedoyin A. and Bankole, Olukayode O. (2019) COMPARATIVE IN-VITRO ANTISICKLING ACTIVITIES OF UNRIPE FRUIT AND LEAVES OF CARICA PAPAYA LINN. In: 1st National Conference of WITED, Ilaro Chapter, August 13-16, 2019, The Federal Polytechnic, Ilaro.
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Abstract
Sickle cell sickness (SCD), otherwise called drepanocytosis is a genetic blood issue, described by a variation from the norm in the oxygen conveying hemoglobin molecule in red blood cells. Extracts of Carica papaya (Caricaceae) leaves and unripe fruits have been validated to have antisickling activities. This study analyzed the comparative in vitro antisickling properties of the extract and fractions of C. papaya leaves and unripe fruits. In-vitro antisickling studies were carried utilizing blood samples from sickle cell disease patients with normal saline and parahydroxybenzoic acid as negative and positive controls respectfully. Results confirmed the antisickling potency of both plant material used in this investigation. The extract and fractions reversed sickling in a dose-dependent manner. The unripe fruit was observed to be more potent having 2% (methanol), 3% (ethyl acetate), 4% (aqueous) percentage sickling in comparison with the leaf extract and fractions which has 3% (Methanol), 6% (Ethylacetate), 9% (aqueous) percentage sickling. Summarily, the unripe fruit of C. papaya has more antisickling activities when contrasted with the leaves. These outcomes demonstrate the possibility of C. papaya leaves and unripe fruits as an appealing potential possibility for the management of Sickle cell disease.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QK Botany |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Mr Taiwo Egbeyemi |
| Date Deposited: | 11 May 2020 19:17 |
| Last Modified: | 11 May 2020 19:17 |
| URI: | http://eprints.federalpolyilaro.edu.ng/id/eprint/77 |
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