PROTECTIVE ROLE OF METHANOLIC EXTRACT OF GOMPHRENA CELOSIODES LEAVES ON ACIDIFIED ETHANOL-INDUCED GASTRIC ULCER IN MALE WISTAR RATS

Fafioye, Abisoye and Omotayo, Olakunle (2019) PROTECTIVE ROLE OF METHANOLIC EXTRACT OF GOMPHRENA CELOSIODES LEAVES ON ACIDIFIED ETHANOL-INDUCED GASTRIC ULCER IN MALE WISTAR RATS. In: 1st National Conference of WITED, Ilaro Chapter, August 13-16, 2019, The Federal Polytechnic, Ilaro.

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Abstract

This study was designed to investigate the effect of the methanol extract of Gomphrena celosioides leaves on acidified ethanol-induced gastric ulcer in male Wistar rats. It examined the in vivo antioxidant effect and also the antiulcer potentials of Gomphrena celosioides leaves. Methanol extract of Gomphrena celosioides leaves was administered at 200, 400 and 800 mg/kg body weight by oral gavage and control group received 50mg/kg cimetidine. The treatment lasted for 14 days. In vivo antioxidant enzymatic activity, ulcer parameters and histological evaluation of gastric mucosa were assessed. Administration of acidified ethanol decreased the activities of antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPx) in the untreated ulcerated group with an increase in the levels of malondialdehyde (MDA), and the activity of xanthine oxidase (XO). A decrease in the concentration of reduced glutathione (GSH) was observed in the untreated ulcerated group. However, post treatment with either the extract or cimetidine showed a concentration dependent increase in the activities of SOD, GPx, and the levels of GSH with concomitant decrease in levels of LPO and the activity of XO. The histopathology of the gastric mucosa from rats in the untreated ulcerated group showed sections of leucocyte infiltration and disruption in the epithelial layer, lamina propria, muscularis mucosa and muscular layer which was restored in ulcerated rats post treated with Gomphrena celosioides leaves. Our data indicate Gomphrena celosioides leaves has profound antiulcer properties and is able to protect the gastric mucosa from ethanol induced gastric lesions. The antiulcer properties of the plant might be mediated through its free radical scavenging activity.

Item Type:	Conference or Workshop Item (Paper)
Subjects:	Q Science > Q Science (General)
Divisions:	Faculty of Engineering, Science and Mathematics > School of Chemistry
Depositing User:	Dr J. Soyemi
Date Deposited:	28 May 2021 15:34
Last Modified:	28 May 2021 15:34
URI:	http://eprints.federalpolyilaro.edu.ng/id/eprint/1432

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