Oderinde, A. and Abdussalam, F. (2018) ANTI-PLASMODIAL REMEDY OF FOUR DIFFERENT BOTANICALS (LEAVES AND STEM EXTRACTS) IN MICE INFECTED WITH PLASMODIUM BERGHEI. In: 1st International Conference and Exhibition on Technical Innovation and Global Competition, 5th – 8th November, 2018, The Federal Polytechnic, Ilaro.
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Anti-plasmodial remedy of four different botanicals in mice infected with Plasmodium berghei.pdf Download (95kB) |
Abstract
Azadiracta indica, Carica papaya, Morinda lucida and Alstonia boonei are common medicinal plants used widely in Nigeria for the treatment of malaria and other life threatening ailments. Many efforts are being sacrificed to develop more potent and cheaper anti-malarial of plant origin to combat and replace the various antimalarial drugs that no longer resist the effect of plasmodium. This work was set out to investigate the anti-plasmodial effect of the four botanical extract in plasmodium berghei infected mice using the Peter’s 4-days suppressive test. 25 healthy BALB/c mice of average weight 13.5g were divided into 5 groups of 5 mice each. Group 1 was the negative control given 5mg/kg/bw of normal saline solution while group 2-5 were inoculated intra-peritoneally plasmodium berghei parasitized red blood cell, followed by daily administration of the four ethanolic extract. Administration of 20, 40, 80, 120, 240 and 300mg/kg/bw of the extract showed significant (p<0.05) suppression of plasmodium berghei load in mice infected. Each of the extract was dose dependent as LC50 was observed at 80mg/kg/bw for Alstonia boonei, Morinda lucida and Carica papaya and 120mg/kg/bw for Azadiractaindica. The result of this study showed that the four ethanolic leaf and stem extract possesses potent antimalarial effects and may therefore offer a potential drug lead for development of a safe, effective and affordable antimalarial.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Mr Taiwo Egbeyemi |
| Date Deposited: | 30 May 2020 12:40 |
| Last Modified: | 30 May 2020 12:40 |
| URI: | http://eprints.federalpolyilaro.edu.ng/id/eprint/132 |
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