Identification of Important Interacting Proteins responsible for Merozoites Invasion in Human RBCs

Soyemi, Jumoke and Isewon, Itunuoluwa and Oyelade, Jelili and Adebiyi, Ezekiel (2018) Identification of Important Interacting Proteins responsible for Merozoites Invasion in Human RBCs. In: 11TH CONFERENCE OF THE AFRICAN SOCIETY OF HUMAN GENETICS (AFSHG) AND H3AFRICA CONSORTIUM, 19 SEPT -21 SEPT 2018, KIGALI, RWANDA. (Submitted)

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Abstract

Prevention of infectious disease requires better insight into the molecular crosstalk between host and parasite. Unfortunately,experimental identification of host-parasite protein interaction remains very challenging and hence the computational prediction becomes essential. Merozoites invasion of the Red Blood Cells (RBCs) has been identified as an essential stage crucial to the survival and pathogenesis of the parasite and a stage in which clinical manifestation occurs. New interest has also been built to identify and develop vaccines and drugs that target RBCs invasion because some proteins and processes needed for invasion are unique as well as essential to the parasite This study, therefore, predicted important interacting proteins between human Red Blood Cells and Plasmodium falciparum merozoites based on RNA-Seq gene expression profiles using K-nearest neighbour supervised machine learning algorithm. The predicted results were also validated against computational predictions from literature with 63% of the result being consistent with literature and 37% novel to this study. The important interacting proteins could be used as drug targets for vaccine development against the parasite invasion of the red blood cells

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Q Science > Q Science (General) Q Science > QA Mathematics Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Divisions:	Faculty of Engineering, Science and Mathematics > School of Electronics and Computer Science
Depositing User:	Dr J. Soyemi
Date Deposited:	10 May 2020 13:41
Last Modified:	10 May 2020 13:41
URI:	http://eprints.federalpolyilaro.edu.ng/id/eprint/65

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