Olasunkanmi, Adedoyin A. and AFUYE, OLUKOREDE (2022) INVITRO ANTIDIABETIC ACTIVITY OF ETHANOL AND METHANOL EXTRACTS OF RHUS LONGIPES. In: roceedings of the 3rd International Conference, The Federal Polytechnic, Ilaro, 16th & 17th Aug, 2022, 16-17 August, 2022, The Federal Polytechnic Ilaro, Ogun State, Nigeria.
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Abstract
Diabetes mellitus is a condition which impairs the ability of the body to take up glucose, otherwise known as blood sugar; the interest of using natural antidiabetic as a means of treatment exists. This study shows the in vitro analysis of the antidiabetic effect of methanolic and ethanolic extracts of Rhus longipes. Antidiabetic activity was determined by assessing the activities of alpha-amylase and alpha-glucosidase enzymes. The standard (acarbose) exhibited higher alpha amylase activity when compared to the methanolic and ethanolic plant extracts with IC50 values of 56.73μg/ml, 62.10μg/ml, and 68.79μg/ml, respectively. The alpha-glucosidase activities show that the standard (acarbose) exhibited higher activity when compared to the methanolic and ethanolic plant extracts with IC50 values of 29.27μg/ml, 51.11μg/ml, and 31.00μg/ml respectively. The antidiabetic effects were found to be dose-dependent. The results indicate that Rhus longipes possess antidiabetic properties to varying degrees. Therefore, it could be used to develop natural drugs which may be used in lieu of commonly used strong allopathic drugs which possess a number of harmful side effects.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Mr. Bolanle Yisau I. |
| Date Deposited: | 04 Jul 2023 04:05 |
| Last Modified: | 04 Jul 2023 04:05 |
| URI: | http://eprints.federalpolyilaro.edu.ng/id/eprint/2302 |
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