Oderinde, Abdulganiyu Olumuyiwa and Bankole, Olukayde Olusola (2019) Evaluation of In-vivo Curative and Haematopoietic Effect of Three Chinese Teas in Plasmodium bergheiInfectedMice. IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS), 14 (1). pp. 52-61. ISSN e-ISSN: 2278-3008, p-ISSN: 2319-7676.
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Abstract
The emerging resistance of Plasmodium species to currently available antimalarial drugs remains a public health problem, hence the need for new effective, safe and affordable drugs. The curative and haematopoietic activities of 200 mg/kg and 400 mg/kg body weight of crude ethanolic extract of three commercial Chinese green teas (BIA 849, TD 570 and GB/T19598) were assessed utilizing Rane’s curative antiplasmodial assay in mice infected with Plasmodium berghei (NK65 strain). The impact of the extracts on weight of the creatures were also determined. 200 mg/kg bwt of BIA 849 and GB/T19598 were as potent as 5 mg/kg bwt of chloroquine, with 100 % curative activities at 3 days post-treatment. TD570 at 200 mg/kg bwt was more powerful in stifling plasmodium, having 100 % curative activity at 4 days post treatment. 400 mg/kg body weight of TD570 and GB/T19598 extracts were stronger than chloroquine having 100 % curative activities at 2 and 3 days post treatment. Antiplasmodial treatment with the extracts altogether increased WBC count of the groups. Reduction in RBC count of infected mice was resisted significantly by treatments with respect to the untreated gathering, while Hb concentration increased significantly. Weight changes were most significant with 400 mg/kg bwt of GB/T19598 treated group (3.18 % decrease) on curation in respect to 0 % and 1.75 % decrease in positive control group respectively. All in all, the green teas displayed high antiplasmodial and haematopoietic possibilities and are hence prescribed as contender for additionally screening as elective antimalarial drugs.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Chemistry |
| Depositing User: | Mr Taiwo Egbeyemi |
| Date Deposited: | 11 May 2020 20:18 |
| Last Modified: | 11 May 2020 20:18 |
| URI: | http://eprints.federalpolyilaro.edu.ng/id/eprint/104 |
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