Akanbi, O. O. and Edeki, S. O. and Agbolade, O. A. (2017) Continuous-time model and physical simulation of population dynamics of sickle cell anaemia. International Journal of Advanced and Applied Sciences, 4 (6). pp. 14-18.
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Abstract
Sickle Cell Disease (SCD) is a potentially devastating condition that is caused by an autosomal recessive inherited hemoglobinopathy which results in the vaso-occlusive phenomena and hemolysis. Sickle Cell Anaemia (SCA) is the most common form of SCD. As such, this paper provides an insight on the mathematical transmission dynamics of SCA and develops a physical realistic model. A female dominant renewal equation of birth dynamics was developed. Hardy-Weinberg equation is applied to obtain the frequency of different genotype groups for the physical simulation. We realized an average of 70% neonates normal (AA), 27% carrier (AS), and 3% sicklers (SS), which is typically the real world result. This implies that physical simulation is an effective tool in predicting the genetic make-up of any population.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QA Mathematics |
| Divisions: | Faculty of Engineering, Science and Mathematics > School of Mathematics |
| Depositing User: | Mr Taiwo Egbeyemi |
| Date Deposited: | 22 Jun 2020 14:35 |
| Last Modified: | 22 Jun 2020 14:35 |
| URI: | http://eprints.federalpolyilaro.edu.ng/id/eprint/752 |
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