Olugbemi-Adesipe, Iyanuoluwa and Solomon, Oladapo Rotimi Alteration in Antioxidant Status and Apoptotic Genes in Rat Liver Following Treatment with Gatifloxacin. In: 16th iSTEAMS Multidisciplinary Research Nexus Conference.
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Abstract
Aim: Gatifloxacin (GTX) - an 8-methoxy fluoroquinolone antibacterial agent is known to be very effective in the treatment of respiratory and urinary tract infections. This study investigates the toxic potentials of GTX in Wistar rat liver. Methodology: Adult rats were exposed to oral doses (10 mg/kg, 20 mg/kg, 40 mg/kg and 80 mg/kg) of gatifloxacin for five days. Thereafter, biomarkers of oxidative stress were assessed spectrophotometrically while the levels of expression of Bcl2l1, caspases 3, 8 and 9 were assessed using reverse transcription polymerase chain reaction technique. Results: The results showed that GTX induces hepatic oxidative stress as well as increased expression of proapoptotic genes. Conclusion-These alterations observed at the lowest dose of 10 mg/kg showed that gatifloxacin exposure could induce hepatic apoptosis.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Depositing User: | Mr Taiwo Egbeyemi |
| Date Deposited: | 11 May 2020 19:03 |
| Last Modified: | 11 May 2020 19:03 |
| URI: | http://eprints.federalpolyilaro.edu.ng/id/eprint/68 |
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