Functional enrichment of human protein complexes in malaria parasites

Soyemi, Jumoke and Isewon, Itunuoluwa and Oyelade, Jelili and Adebiyi, Ezekiel (2017) Functional enrichment of human protein complexes in malaria parasites. In: Conference: 2017 International Conference on Computing Networking and Informatics (ICCNI), 29-31 Oct. 2017, Lagos, Nigeria.

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Abstract

This study extracted differentially expressed genes (DEG) from a RNA-Seq gene expression experiment of human red blood cells for both case and control. A protein interaction network (PIN) for the DEG at the red blood stage was extracted from protein interaction database. From the protein interaction network built, we identified 64 protein complexes using the molecular complex detection (MCODE) algorithm in Cytoscape. The functional enrichment of the identified protein complexes revealed functions related to rRNA processing, Ribosome biogenesis, RNA metabolic process, cellular process, Nucleic and metabolic process and much more which are active in the RBCs that could be open to invasion by Plasmodium falciparum.

Item Type:	Conference or Workshop Item (Paper)
Subjects:	Q Science > Q Science (General) Q Science > QA Mathematics Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Divisions:	Faculty of Engineering, Science and Mathematics > School of Electronics and Computer Science
Depositing User:	Unnamed user with email [email protected]
Date Deposited:	04 May 2020 19:38
Last Modified:	04 May 2020 19:39
URI:	http://eprints.federalpolyilaro.edu.ng/id/eprint/36

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